Publications and Reports

Selected Publications, Reports and Presentations:

Long-term administration of Trappsol ® Cyclo ™ (HP-B-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick disease type C1: Results of an international 48-week Phase I/II trial.  Reena Sharma, Julian Raiman, Martin Paucar-Arce, Orna Staretz-Chacham, Ronen Spiegel and Sharon Hrynkow.   Molec. Genetics & Metabolism Reports, 2023 Jun 29: 36: 100988. 

Intravenous HPBCD demonstrates activity and impacts cholesterol metabolism in the central nervous system and peripheral tissues in adult patients with Niemann-Pick Disease type C1:  Results of a Phase I trial.  Caroline Hastings, Benny Liu, Bryan Hurst, Gerald Cox and Sharon Hrynkow.  Molec. Genetics & Metabolism, 2022 Dec; 137 (4): 309-319. 

International Niemann Pick Disease Alliance Bi-Annual Conference, “Cyclo Therapeutics’ Update on Its Clinical Programs in Niemann Pick Disease Type C1.”  August 2021, virtual presentation. Lori Gorski, Julian Raiman, MD, Gerald Cox MD, and Sharon Hrynkow PhD

How to Overcome the 3 Major Challenges in Conducting Rare Disease Clinical Trials, Sharon Hrynkow.  Clinical Leader, an industry newsletter which receives over 15,000 visitors per month, published November 30, 2021.  https://www.clinicalleader.com/doc/how–to–overcome–the–majorchallenges–in–conducting–rare–disease–clinical–trials–0001. 

The Rare Disease Report on Niemann-Pick Disease, Sharon Hrynkow.  Podcast for physicians and healthcare professionals.  August 4, 2021.  https://www.hcplive.com/view/rare-disease-report-podcastniemann-pick-disease.

Industries of the Future Institutes: A New Model for American Science and Technology Leadership.  A Report to the President of the United States of America from the President’s Council of Advisors on Science and Technology, January 2021.  Sharon Hrynkow and other members of PCAST, Co-Authors.  Accessible at https://science.osti.gov/-/media/_/pdf/about/pcast/202012/PCAST—IOTFI-FINAL-Report.pdf?la=en&hash=0196EF02F8D3D49E1ACF221DA8E6B41F0D193F17

Expanded Access with intravenous hydroxypropyl-beta-cyclodextrin to treat children and young adults with Niemann-Pick disease type C1: a case report analysis.  Caroline Hastings, Camilo Vieira, Benny Liu, Cyrus Bascon, Claire Gao, Raymond Wang, Alicia Casey and Sharon Hrynkow.  Orphanet J Rare Dis. 14, 228 (2019).

The Global Virus Network: Challenging Chikungunya.  E. McSweegan, S.C. Weaver, M. Lecuit, M. Fineman, TE Morrison, and S. Hrynkow. Antiviral Res. 2015 Aug; 120: 147-52.

The West Africa Ebola Epidemic Arouses Global Response – But Caution Needs an Ally and a Local Interpreter, Sharon Hrynkow.  Huffington Post Blog, October 2014.

Merged Cultures to Empower Women.  Kerri-Ann Jones, Shirley Malcom and Sharon Hrynkow.  Editorial in Science. 2011 Apr 8; 332(6026):149.

Medical Research and Social Entrepreneurship Communities:  Increasing Dialogue May Lead to New Insights for Public Health.  Sharon H. Hrynkow.  Invited chapter.  IOM (Institute of Medicine). 2009. Global Issues in Water, Sanitation and Health.  Washington, DC:  The National Academies Press.

Climate Change and Health Research: Time for Teamwork.  Sharon Hrynkow.  Editorial in Environmental Health Perspectives 116 (11): 470 (2008).

Disease Control Priorities in Developing Countries.  Sharon Hrynkow, Advisor to the Editors.  Published by The World Bank and Oxford University Press.  2006.  see www.dcp2.org

U.S. International Strategy on HIV/AIDS, State Department publication 10296.  Chief drafter.  (1995).